ChemicalBook >> CAS DataBase List >>H-7 DIHYDROCHLORIDE
H-7 DIHYDROCHLORIDE
- CAS No.
- 108930-17-2
- Chemical Name:
- H-7 DIHYDROCHLORIDE
- Synonyms
- H-7;H-7 DIHYDROCHLORIDE;H-7 (hydrochloride);H-7 dihydrochloride,98%;H7 dihydrochloride,H 7 dihydrochloride;Protein kinase inhibitor H-7 dihydrochloride;1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL;1-(5-isoquinolinylsulfonyl)-2-methylpiperazine 2HCl;H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem;(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
- CBNumber:
- CB3725838
- Molecular Formula:
- C14H19Cl2N3O2S
- Molecular Weight:
- 364.29
- MDL Number:
- MFCD00036961
- MOL File:
- 108930-17-2.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| Melting point | 215-225 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: 20 mg/mL |
| form | Light yellow lyophilized solid |
| color | White to Off-White |
| BRN | 5840763 |
| CAS DataBase Reference | 108930-17-2(CAS DataBase Reference) |
| FDA UNII | 55VT8U9HB1 |
H-7 DIHYDROCHLORIDE price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I7016 | H-7 dihydrochloride ≥98% (HPLC) | 108930-17-2 | 5mg | $136.8 | 2024-03-01 | Buy |
| Alfa Aesar | J61697 | H-7 dihydrochloride | 108930-17-2 | 10mg | $165.65 | 2024-03-01 | Buy |
| Alfa Aesar | J61697 | H-7 dihydrochloride | 108930-17-2 | 50mg | $721 | 2023-06-20 | Buy |
| Cayman Chemical | 21434 | H-7 (hydrochloride) ≥98% | 108930-17-2 | 5mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 21434 | H-7 (hydrochloride) ≥98% | 108930-17-2 | 10mg | $95 | 2024-03-01 | Buy |
H-7 DIHYDROCHLORIDE Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Uses
A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases
Uses
H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.
Definition
ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride.
General Description
A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (Ki = 97 μM), protein kinase A (Ki = 3.0 μM), protein kinase C (Ki = 6 μM), and protein kinase G (Ki = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.
Biochem/physiol Actions
Target Ki: 3.0 μM, 97 μM, 6.0 μM, 5.8 μM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively
storage
Store at RT
H-7 DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
H-7 DIHYDROCHLORIDE Suppliers
Global( 72)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9901 | 58 | |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
108930-17-2(H-7 DIHYDROCHLORIDE)Related Search:
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1of4
H-7 DIHYDROCHLORIDE
H-7
(+/-)-1-(5-ISOQUINOLINESULPHONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE DIHYDROCHLORIDE
(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
(-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE, DI-HCL SALT
(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE
1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE
1-(5-isoquinolinylsulfonyl)-2-methylpiperazine 2HCl
H-7 dihydrochloride,98%
Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride
5-[(2-Methyl-1-piperazinyl)sulfonyl]isoquinoline Hydrochloride
H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem
H-7 (hydrochloride)
H7 dihydrochloride,H 7 dihydrochloride
5-((2-Methylpiperazin-1-yl)sulfonyl)isoquinoline dihydrochloride
Protein kinase inhibitor H-7 dihydrochloride
108930-17-2
C14H19Cl2N3O2S
Cell Biology
Serine/Threonine Kinase Inhibitors
Kinase/Phosphatase Biology
Protein kinase A and protein kinase C (PKA and PKC)
BioChemical
Cell Signaling and Neuroscience
Protein Kinase Inhibitors and Activators